In addition to "doing everything right", I think there are 6 other ideas that can help lower the manufacturing cost of a PCB.
1. Understanding First Pass Yield (FPY) in Mfg.- The mfg. yield of a PCB can be predicted for a particular fabricator by 'calibrating' that fabricator's capability. 75% of the cost of a PCB is based on the design (20 - 25% is cost of inventory and factors not related to the PCB process) and average yield is based on how "complex" the design is. More layers, finer lines, larger size, smaller holes, total number of holes, etc all make the PCB 'complex' to manufacturer. So once you have a fabricators "Capability Coefficients", you can take the PCB Complexity Index (made up of critical design features) and estimate the FPY. This can be as accurate as +/- 3-5% if the fabricator has his manufacturing process under control (not to much design can do if employees are not trained, quality procedures not observed or equipment not maintained). This FPY provides insight into how much this design will cost with this fabricator.
2. Selecting the best PCB materials to lower costs-Many are not familiar with the mfg's of laminates in Asia, even though they are now the largest materials suppliers in the world. NanYa Plastics, Panasonic and Kingboard are No. 1, 2 & 3 in the world. Because of this they have some of the lowest priced FR-4 laminates that meet all the MIL & IPC specs for FR-4, including lead-free assembly. Newer laminators like ITEQ, ShengYi, Doosan, Chang Chan, Grace and TUC are now also in the North American market selling their laminates. Since laminate is the single largest cost of a PCB, it makes reviewing these new suppliers worth the effort.
3. How to reduce layers in a PCB multilayer-Mentor has developed a better strategy for fanout of BGAs > 400 pins that can lead to reducing the number of signal layers in a board. If HDI-microvias are also used, then the layer reduction can be significant with these new 'aligned-via patterns'. The layer reduction is large enough to pay for the increased price of HDI, plus some extra!
4. Design for Fab (DFF) Best Practices-Nothing beats "Best Practices" in terms of design rules, spacings and other layout techniques that minimize fabrication and assembly problems.
5. Understanding if a PCB Fabricator is Capable of building your design at high FPYs.- What if a fabricator's FPY is low for your design? IPC has created a Benchmarking Program that test a fabricators capability, the IPC-9151 Benchmarking Panels. This is a set of PCB panels from 2 to 24 layers, created with different hole, pad, trace and spacing geometries. The artwork is free and available at http:///www.pcbquality.com . A fabricator can download the artwork and build the Benchmarked panels. There are two licensed facilities that have the extensive test equipment to evaluate these panles and produce the comprehensive report. The Program is called PCQR2, for Process Capability, Quality and Relative Reliability, because it also takes the via daisy-chains and subjects them to 500 cycles of -45C to 145C. The panels are designed to provide a 99% confidence of only a 1% error statistically in the data.