Your parameters are reasonable. Here are a few suggestions to help in your analysis.
1- Remember that Quick Analysis is just an equation calculation, so the crosstalk is just an estimate. I use the Quick Analysis to find the potentially large errors, and then run a detailed simulation on just the nets that show large estimates of crosstalk. For the Quick Analysis, I set the threshold about 1/2 of the real threshold that I want to check. This allows for errors in the estimate.
2- Since this is an estimate, I suggest using aggressive parameters for the Default IC Characteristics. Assume fastest strongest driver and lowest pin capacitance.
3- The Quick Analysis can use parameters from actual IBIS models if you have them assigned to parts. Since this is DDR4, it should be fairly easy to find IBIS models. I suggest assigning the models before running Quick Analysis. This will provide better estimates of crosstalk. Then you can run full detailed simulations of the nets that show higher estimated crosstalk.
4- The correct threshold for detailed simulation crosstalk is a matter of design impact. To start with, I suggest allowing about 1/3 of noise margin to crosstalk. If you are designing a high-reliability product, then you might use a lower crosstalk threshold. If your product is focused more on speed or low cost, then you can allow a higher threshold.
I hope that these suggestions are helpful in your design and analysis.
Thanks much for your feedback, Weston_beal.
If you have a minute, could you please mark the reply with the correct answer? this will remove your question from the list of UNanswered questions.