This question of the comparison would be best answered by your Sales Team without divulging your simulation requirements in this online forum, But...
Yes! HyperLynx Analog supports mixed signal simulation. HyperLynx Analog is a front end integrating DxDesigner schematics to several simulation tools including.
A Base SPICE simulator included with HLA
The ELDO SPICE simulator
Questa ADMS Analog/Mixed-Signal Verification
Although the integration of Schematics to Models differs from that used in System Vision, System Vision is also built on a version of the Questa ADMS simulator. HLA is specifically designed to simulate subsections of a PCB up to the entire PCB, without impacting the ability to create a correct by construction printed circuit board.
HLA also functions well and is supported in both the Windows and Linux operating system environments.