I recommend vb.net. Here's a thread with an automation template with everything you need to get started with all the Xpedition flow tools - DxDesigner, Xpedition, Fablink, and Drawing Editor.
vb.net is vastly more flexible and powerful than any of the vbscript variants. Caveat is that it's not officially supported by Mentor, but there are countless examples of how to do things on the web and somebody here has probably encountered every situation you'll ever run into interfacing with the Mentor tools, and we're glad to help out.
I use the debugger in Microsoft Excel and load the Xpedition Type Library. I outline the steps and example in:
You can add watches, breakpoints, strong typing/command completion.... It gives you the how to take that and make a regular .vbs script or add your code to a form.