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1) Setup your design as needed.
2) Select 'File > Save As Start-up file...'. It is normally being placed in the \Settings\ directory.
3) If you afterwards select 'File > New' then the new start-up file should be visible in the 'Set Start-up File' dialog. It works pretty well.
Note that you cannot save an entire design into a start-up file.Only a few specific settings can be saved:
Thanks for the answer. I think this is it. Basically I don't need traces, vias and parts as a new start-up. I will try it later today.