This was also posted in 'Ask the Expedition Enterprise Insider'
The response here was:
"Have you tried the Scale factor setting in the Display / Font Mappings section of the Settings dialog? Map the builtin fonts to a scalable font, and change the scale factor. This is stored in the DxDesigner.xml file, so it can be a user-specific setting.
Thanks! This solution helps. It is at least a start though it is all inclusive of a certain font which does cause other issues. In dream land, a more selective criteria would be helpfule as well.
If you think it would be a worthwhileenhancement then post it as an Idea on the Mentor Ideas site under DxDesigner.