Only by using Databook with DxWebpack - this allows the database to be hosted on a system where the conflicts with the 64 & 32-bit ODBC drivers don't apply. The limitation is with Microsoft's drivers and not Mentor products. Look on SupportNet or Support Center for details about setting up DxWebPack (Tech Note MG58142)
When we upgraded to VX.2.2, we switched to using the newly supported SQLite database format which doesn't need ODBC drivers. So far so good on the switch.